Editor’s Word: This text is a reprint. It was initially printed July 2, 2023.

On this video, I interview repeat visitor Dr. Dale Bredesen, a neurologist specializing within the therapy of Alzheimer’s. In 2014, he printed a paper¹ demonstrating the facility of way of life selections for the prevention and therapy of this tragic situation. By leveraging 36 wholesome way of life parameters, he was capable of reverse Alzheimer’s in 9 out of 10 sufferers.

Randomized Trial Launch

For starters, his staff has printed one other proof-of-concept paper and at the moment are launching a randomized, managed trial at six websites: Hollywood, Florida; Nashville, Tennessee; Cleveland, Ohio; and Sacramento, Oakland and San Francisco in California.

Organic growing old, mind growing old and epigenetics can be assessed on this trial, utilizing newer blood checks that weren’t out there even just a few years in the past, together with phospho-tau 181, phospho-tau 217, A-beta 42 to 40 ratio, glial fibrillary acidic protein (GFAP) and neurofilament gentle polypeptide (NF-L).

“A few these aren’t commercially out there but, so we’re doing these as analysis, however they may all develop into commercially out there,” Bredesen says. “Presently, phospho-tau 181 is commercially out there and so is the A-beta 42 to 40 ratio. So now, for the primary time, you will get an concept, with out essentially having a PET scan, the place you stand.

Extra importantly, you’ll be able to comply with it as you enhance. Prevention is vital, but in addition reversing cognitive decline, which we had been the primary to do … We have seen it many times, while you’re doing the suitable issues, while you’re attacking the necessary drivers of the method, you see [reversal].”

Helpful Exams

The GFAP check, whereas nonspecific, could be a beneficial device. This check principally seems to be at mind modifications related to astrocytosis. Astrocytes reply when there’s an issue within the mind, so it may give you a heads-up that one thing is afoot as much as 10 years earlier than signs develop into obvious. “The excellent news is that if it is regular, you are in fairly fine condition. So that you wish to know that going ahead,” he says.

The phospho-tau 181 and phospho-tau 217 are particular checks for Alzheimer’s modifications associated to the loss of life of neurons. Genetic testing can also be necessary to establish what number of copies of the APOE ε4 gene you might need. “That is a crucial piece,” Bredesen says. “Everyone ought to know their APOE standing.” Hormone testing and testing for toxins, together with mycotoxins and heavy metals, are additionally necessary.

The place There’s Smoke There’s Fireplace

In response to standard thought, elevated tau and beta-amyloid are causative elements in Alzheimer’s, however Bredesen’s analysis suggests in any other case. He explains:

“It is a little bit like saying, ‘There’s some smoke there. If we simply blow away the smoke, then the home isn’t going to burn down.’ It is unnecessary. The important thing factor to know is that [tau and beta-amyloid] are responses and mediators. You’ve got talked lots about mitochondrial operate, which is totally crucial on this illness, however we all know of many upstream contributors, and that is one other replace.

Folks haven’t identified what’s inflicting this illness, and it is typically stated there’s nothing that stops, reverses or delays it. Nothing could possibly be farther from the reality. We all know there are a lot of contributors, [including] something that damages mitochondria [and] totally different infections.

What we now see from the analysis is that Alzheimer’s illness essentially is a community insufficiency. You will have this stunning community of about 500 trillion synapses and as you get uncovered to irritation, infections in your mouth, insulin resistance, leaky intestine, not sufficient blood circulate, diminished oxygenation, diminished mitochondrial operate, any of this stuff, that community is now not sufficiently supported.

And, no shock, it pulls again and that is why you see the tau. They’re a part of the mediators of creating this impact enhanced. They amplify the issue. Dr. Lee Hood and Dr. Nathan Worth have simply printed a beautiful guide known as ‘The Age of Scientific Wellness,’ and as they level out, amyloid is a wonderful biomarker however a horrible therapeutic goal, and that is precisely what’s popping out of the info.

Sadly, Lecanemab was simply advisable by the panel for FDA approval. It slowed the decline. However here is the factor they did not say, which they need to have stated, what are the issues that carried out higher? Lecanemab does not make you higher, it does not preserve you an identical, it slows the decline by 27%. That is it.

So what labored higher of their trials? No. 1, ketones alone labored higher than this drug. No. 2, further virgin olive oil alone in a trial labored higher than this drug. No. 3, mixed metabolic activators — carnitine, nicotinamide, riboside, issues like that. Once more, supporting energetics. That is about energetics and irritation. These are the 2 massive gamers.

After which in fact, the protocol we developed labored the very best of something. We have got folks now who’ve sustained their enchancment for greater than 10 years. So, it is unhappy that this drug has been advisable for approval.”

Two Key Causative Elements That Should Be Addressed

In response to Bredesen, supporting power and lowering irritation within the mind are the 2 most necessary elements to stop and deal with Alzheimer’s. Fundamentals that each one of Bredesen’s sufferers implement embrace:

Dietary intervention — Bredesen recommends a plant-rich, mildly ketogenic food regimen, with omega-3 to omega-6 ratio, no dairy, no grains and no easy carbs. “That is the strategy that has labored the very best,” he says. “We name that KetoFLEX 12/3.” Vitamin for Longevity now presents meal kits for the KetoFLEX 12/3 food regimen at KetoFlex123.com, to make it simpler to comply with. Within the interview, I counter a few of Bredesen’s dietary suggestions, as he nonetheless recommends polyunsaturated fat (PUFAs). I’m satisfied all omega-6 PUFAs must be stored low, under 2% and even 1% of every day energy, for optimum well being, and I strongly suspect folks with dementia must be much more cautious, because the PUFA linoleic acid (LA) seems to be the largest dietary supply of all of the drivers of Alzheimer’s, together with irritation, oxidative stress, mitochondrial dysfunction and dysfunction in electron transport chain such that you simply can not effectively produce ATP. I’ve written extensively on the ins and outs of this, so for extra data, hearken to the interview and/or evaluation “Linoleic Acid — The Most Damaging Ingredient in Your Weight-reduction plan.” I’m additionally not satisfied that the omega-3 to omega-6 ratio is as useful as generally recommended since you can’t counter the harm brought on by omega-6 fat just by taking extra omega-3. On high of that, most omega-3 dietary supplements, primarily fish oil, are nugatory as a result of they’re artificial and rancid in addition, so ensuring you’re getting high-quality omega-3 is a necessary issue. Lastly, since this interview, I’ve come to understand the significance of carbs for mind well being, together with easy carbs from entire fruits, and the drawbacks of long-term keto. So, please perceive, Bredesen’s dietary suggestions are his personal, primarily based on his analysis, and don’t essentially replicate my very own views.

Train — Bredesen is seeing significantly good outcomes with KAATSU (blood circulate restriction coaching) and train with oxygen remedy (EWOT).

Sleep optimization — Sleep apnea is a standard downside that unquestionably contributes to cognitive decline, because it reduces oxygen to your mind and raises adrenaline when you’re sleeping. “Sleep is a big space in and of itself,” Bredesen says. “Affected person zero, the primary particular person we handled again in 2012 who reversed her cognitive decline fantastically, she’s now over a decade in on this, doing nice frequently. She’s now in her late 70s. Certainly one of her points was poor sleep and, in fact, one of many issues that was addressed. Getting at the least an hour of deep sleep and at the least an hour and a half of REM sleep could be very useful … Poor sleep provides you extra amyloid. It is only a marker, however it’s a marker of issues that are not so good, and sadly, amyloid then provides you poorer sleep.”

Stress discount

Mind coaching

Detox

Focused dietary supplements

The opposite a part of Bredesen’s program is custom-made to every affected person. Many have undiagnosed persistent infections, for instance, that must be addressed. Frequent ones embrace P. gingivalis and T. denticola, which work their approach into your mind out of your oral microbiome, herpes simplex and human betaherpesvirus 6A (HHV-6A).

All the household of herpes viruses is related to modifications within the mind and neurons. HHV-6A specifically is related to the mind degeneration seen in Alzheimer’s. Chlamydia pneumoniae can also be extremely troublesome, as are all tick-borne infections, together with Borrelia, Bartonella, Babesia and Anaplasma.

All these infections put your innate immune system into overdrive and must be quenched. As famous by Bredesen, COVID-19 and Alzheimer’s are “each innate immune system mismatches with the adaptive system.” You are not clearing the pathogen, so you have acquired this continued onslaught of cytokines. Within the case of COVID, you die from the acute cytokine storm, whereas in Alzheimer’s, you die from cytokine drizzle. “It is a long-term cytokine downside,” Bredesen says.

Excessive-Fructose Corn Syrup Down-Regulates ATP Manufacturing

Bredesen additionally highlights the significance of avoiding fructose. In March 2023, Dr. Richard Johnson, Bredesen, Dr. David Perlmutter and several other different co-authors printed a paper² on Alzheimer’s illness as “a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism.”

“It’s actually the long-term analysis of Rick Johnson. You speak about mitochondrial operate, about harm to mitochondria. He is speaking a few change in sign. They’re each necessary. As he factors out, while you get that fructose, your physique is actually responding to it saying, ‘Winter is coming. We’re going to retailer fats and we will flip down your ATP by about 15%.’

Properly, while you’re proper on the ragged fringe of not getting sufficient energetics, then turning down your ATP by 15% is the very last thing you need and is related to cognitive decline.

Rick put collectively a complete desk taking a look at all of the relationships, modifications in PET scans, modifications in blood biomarkers. In every of those circumstances, what occurs with fructose is identical factor that occurs in Alzheimer’s illness.

So once more, it comes again to the crucial nature of the energetics, whether or not you are turning them down by taking an excessive amount of fructose and high-fructose corn syrup, which isn’t to say you’ll be able to’t eat some fruit, it simply means you do not wish to have large quantities of fructose.”

Fruit vs. Excessive-Fructose Corn Syrup

Right here too, my present views veer a bit. It’s necessary to know there’s a world of distinction between fructose from fruit and high-fructose corn syrup. I used to suggest limiting each sources, however I’ve modified my considering on this, as fructose from fruit prompts pyruvate dehydrogenase, which it’s good to metabolize glucose from pyruvate to acetyl-CoA in your mitochondria. If that enzyme isn’t activated, the glucose can’t be used for gasoline.

The important thing to this riddle for me was the Randle Cycle, which principally acts as a metabolic swap. Your main fuels are fat and carbs, and the Randle cycle determines how your cells resolve which one to burn. When your food regimen is greater than 30% to 35% fats, this swap shifts to fats metabolism, so that you simply’re burning fats in your mitochondria moderately than glucose. The glucose as a substitute will get shuttled into glycolysis and any extra goes out into your blood.

So, consuming a whole lot of fruit and a whole lot of fats on the identical time isn’t a good suggestion. In essence, fructose by itself isn’t what’s inflicting the issue. Reasonably it’s consuming an excessive amount of fructose together with an excessive amount of fats. For those who improve your recent fruit consumption, you additionally must decrease your fats consumption, or else the sugar can’t be used for gasoline.

Moreover, there are particular person variations in metabolic flexibility, toxicity and microbiome that probably contribute to an individual’s capacity to tolerate elevated carbohydrates.

The opposite level of rivalry I’ve is that PUFAs additionally seem to induce torpor (decreased physiological exercise marked by a diminished metabolic fee), very like high-fructose corn syrup does. So, I think ripe fruit isn’t going to be a significant contributor to dementia. In a earlier interview with Johnson, he additionally admitted being stunned that fructose from fruit didn’t have the identical results as high-fructose corn syrup. Bredesen replies:

“Sure. And it makes good sense. The attention-grabbing factor to me is we’re frugivore (animals that thrive on uncooked fruits), we’re descended from frugivores. The issue now we have right now, in fact, is that our fruit has been bred to have a a lot greater sugar content material. That is the problem. However the excellent news is, it retains the great fiber and, as you identified, it does not provide you with that impact that high-fructose corn syrup and processed meals provide you with.”

Methylene Blue, Niacinamide, NAC and Glycine

One therapy adjunct Bredesen favors is methylene blue, which is one thing I like to recommend for almost anybody who desires to enhance their well being and reverse degenerative illness, primarily as a result of it’s so efficient at lowering reductive stress. It facilitates electron switch ahead within the mitochondria, thereby permitting ATP manufacturing to happen, even when the complexes are broken.

Elevating NAD+ can also be necessary for power manufacturing. NAD+ is oxidized, not diminished, so it facilitates the switch of electrons ahead within the electron transport chain. Whereas there are costly precursors on the market, my favourite is obvious previous niacinamide, which is extremely cheap but raises NAD+ successfully.

Analysis has additionally confirmed that niacinamide helps sluggish mind growing old. For basic well being, I like to recommend taking 50 milligrams of niacinamide thrice a day. Niacinamide additionally works synergistically with methylene blue.

Many dementia sufferers even have low glutathione ranges, particularly in the event that they’ve been uncovered to mycotoxins or different toxins. I’m not a fan of taking glutathione, as a result of glutathione is diminished, and also you want the oxidized kind to essentially make it work.

To make the precise glutathione molecule, you want each cysteine and glycine, so one method to enhance your glutathione stage could be to take glycine and N-acetylcysteine (NAC).

Two different methods to get extra glycine into your food regimen are to eat “nostril to tail,” not together with muscle meat, or taking a collagen complement or gelatin powder. “Nostril to tail” refers to organ meats and connective tissues, that are wealthy in collagen. Collagen, in flip, makes up about one-third of the protein in your physique, so it’s extremely necessary. About 30% of the collagen and gelatin is glycine, so it’s a superb supply.

Precision Drugs Program to Launch

Bredesen can also be a part of a staff launching a Precision Drugs Program on the Pacific Neuroscience Institute in Santa Monica, California. This system will work to stop and deal with persistent circumstances in any respect levels, however will deal with getting folks in for prevention and early therapy.

“Once you get Alzheimer’s, you undergo 4 levels,” Bredesen says. “You undergo a presymptomatic section, and also you undergo subjective cognitive impairment (SCI) that lasts on common 10 years. For these areas, prevention and therapy are just about 100% efficient. We will stop, and we are able to reverse nearly each time persons are in SCI.

MCI is the subsequent. It is too dangerous it is known as gentle cognitive impairment. It is like telling somebody they’ve mildly metastatic most cancers. It is a comparatively late stage of Alzheimer’s illness. Nonetheless, in our trial, we had 84% of these folks enhance.

The ultimate stage is dementia. And we nonetheless see some folks with proof of dementia enhance. However the farther you go, the more durable it’s to get all of them the way in which again. So, we encourage everybody, please are available early.

We have had folks go from MoCA [Montreal cognitive assessment] scores of 18 to 30, which is implausible, from demented to regular. We have had folks go from zero to 9. However we have by no means seen anybody but have the ability to go from zero MoCA, which is end-stage Alzheimer’s, to good 30 …

A man wrote me a nasty be aware a pair years in the past, saying ‘How dare you inform people who in the event that they’re too far alongside, they should not get on this protocol? My spouse had a MoCA rating of zero. She’s in a nursing dwelling. We used the protocol that you simply developed, she solely went up just a little bit, however her signs had been so a lot better.’ She may gown herself, she may communicate once more, she may have interaction.

So I do not say there is a restrict, however it’s a lot more durable under 16. You may get some dramatic subjective enhancements. And once more, we have seen folks go from 15 to 27. So, it does occur, it is simply that it’s more durable the longer you wait, which is why we encourage everybody to come back early. If all people would are available in these first two phases — prevention or SCI — dementia could be a uncommon downside.”

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